Solid Dispersion–an Approach to Enhance the Dissolution Rate of Amlodipine

Solid dispersion refers to the dispersion of one or more active ingredients in an inert carrier in a solid state, frequently prepared by the melting method, solvent method, or fusion solvent method. The oral bioavailability of poorly water soluble drug remains as the most challenging aspects of drug development. Solid dispersion approach is to reduce particle size, therefore increases the dissolution rate and absorption of drugs. Amlodipine is poorly soluble drug. The solubility of this drug is enhanced by preparing the solid dispersions of amlodipine, with hydrophilic polymers like PEG4000, in different ratios (1:1, 1:2, 1:3, 1:4, 1:5 and 1:6). The amount of drug released is measured by UV spectroscopy at the wavelength of 238nm using methanol as blank.